1. Was the universe designed by an intelligent entity, or did it come about through random interactions constrained by fundamental physical laws?
2. Why do the fundamental physical constants appear to be "tuned" precisely to support life?
3. Are there many universes (a "multiverse")? If so, maybe they all have different physical constants, and ours is just one of the few that supports life.
4. (Coming full circle...) In the same way that we can simulate life-filled universes in computers, is it possible that some superintelligent entity may have created our universe (perhaps with similar motivations to our own)?
Conway's game of life is used as an enlightening example of complexity arising from a simulated universe based on simple rules. Towards the end it includes some commentary by Nick Bostrom, one of my favorite philosophers.